Higley B, Smith FW, Smith T, Gemmell HG, Das Gupta P, Gvozdanovic DV, Graham D, Hinge D, Davidson J, Lahiri A. Technetium-99m-1,2-bis[bis(2-ethoxyethyl) phosphino]ethane: human biodistribution, dosimetry and safety of a new myocardial perfusion imaging agent. J Nucl Med. 1993 Jan;34(1):30-8
Kelly JD, Forster AM, Higley B, Archer CM, Booker FS, Canning LR, Chiu KW, Edwards B, Gill HK, McPartlin M, et al. Technetium-99m-tetrofosmin as a new radiopharmaceutical for myocardial perfusion imaging. J Nucl Med. 1993 Feb;34(2):222-7.
Patel M, Owunwanne A, Tuli M, al-Za'abi K, al-Mohannadi S, Sa'ad M, Jahan S, Jacob A, al-Bunny A. Modified preparation and rapid quality control test for technetium-99m-tetrofosmin. J Nucl Med Technol. 1998 Dec;26(4):269-73.
Hammes R, Joas LA, Kirschling TE, Ledford JR, Knox TL, Nybo MR, Sterzinger JJ. A better method of quality control for 99mTc-tetrofosmin. J Nucl Med Technol. 2004 Jun;32(2):72-8.
In vitro analysis:
Bernard BF, Krenning EP, Breeman WA, Ensing G, Benjamins H, Bakker WH, Visser TJ, de Jong M. 99mTc-MIBI, 99mTc-tetrofosmin and 99mTc-Q12 in vitro and in vivo.Nucl Med Biol. 1998 Apr;25(3):233-40.
Rodrigues M, Chehne F, Kalinowska W, Berghammer P, Zielinski C, Sinzinger H. Uptake of 99mTc-MIBI and 99mTc-tetrofosmin into malignant versus nonmalignant breast cell lines. J Nucl Med. 2000 Sep;41(9):1495-9.
Arbab AS, Koizumi K, Toyama K, Arai T, Araki T. Technetium-99m-tetrofosmin, technetium-99m-MIBI and thallium-201 uptake in rat myocardial cells. J Nucl Med. 1998 Feb;39(2):266-71.
Animal Studies:
Madar I, Ravert H, Dipaula A, Du Y, Dannals RF, Becker L. Assessment of severity of coronary artery stenosis in a canine model using the PET agent 18F-fluorobenzyl triphenyl phosphonium: comparison with 99mTc-tetrofosmin. J Nucl Med. 2007 Jun;48(6):1021-30.
Constantinesco A, Choquet P, Monassier L, Israel-Jost V, Mertz L. Assessment of left ventricular perfusion, volumes, and motion in mice using pinhole gated SPECT. J Nucl Med. 2005 Jun;46(6):1005-11.
Onoguchi M, Takayama T, Tonami N, Kyogoku S, Naoi Y, Irimoto M, Maehara T. Comparison of 99mTc-tetrofosmin uptakes on planar images with those in excised rats organs. Ann Nucl Med. 2001 Feb;15(1):33-40.
Bernard BF, Krenning EP, Breeman WA, Ensing G, Benjamins H, Bakker WH, Visser TJ, de Jong M. 99mTc-MIBI, 99mTc-tetrofosmin and 99mTc-Q12 in vitro and in vivo.Nucl Med Biol. 1998 Apr;25(3):233-40.
Takahashi N, Reinhardt CP, Marcel R, Leppo JA. Myocardial uptake of 99mTc-tetrofosmin, sestamibi, and 201Tl in a model of acute coronary reperfusion. C...
Clinical Studies:
Elhendy A, Schinkel AF, van Domburg RT, Bax JJ, Feringa HH, Noordzij PG, Schouten O, Poldermans D. Prognostic implications of stress Tc-99m tetrofosmin myocardial perfusion imaging in patients with left ventricular hypertrophy. J Nucl Cardiol. 2007 Jul;14(4):550-4.
Adams GL, Shaw LK, Tuttle RH, Hanson MW, Pagnanelli R, Borges-Neto S. Prediction of mortality in patients with coronary artery disease undergoing vasodilator stress testing: a comparison between 99mTc-tetrofosmin and 99mTc-sestamibi. Nucl Med Commun. 2007 Jun;28(6):457-63.
Higley B, Smith FW, Smith T, Gemmell HG, Das Gupta P, Gvozdanovic DV, Graham D, Hinge D, Davidson J, Lahiri A. Technetium-99m-1,2-bis[bis(2-ethoxyethyl) phosphino]ethane: human biodistribution, dosimetry and safety of a new myocardial perfusion imaging agent. J Nucl Med. 1993 Jan;34(1):30-8
Tamaki N, Takahashi N, Kawamoto M, Torizuka T, Tadamura E, Yonekura Y, Okuda K, Nohara R, Sasayama S, Konishi J. Myocardial tomography using technetium-99m-tetrofosmin to evaluate c...
Examples
Tc-99m Myoview Gated Rat Heart 2008-06-13 Univ. of Ottawa Heart Institute
