Meegalla S.K., Plossl K., Kung M.P., Chumpradit S., Stevenson D.A., Kushner S.A., McElgin W.T., Mozley P.D., Kung H.F.. Synthesis and characterization of technetium-99m-labeled tropanes as dopamine transporter-imaging agents. J Med Chem. 1997; 40 (1):9-17.
Carroll F.I., Abraham P., Lewin A.H., Parham K.A., Boja J.W., Kuhar M.. Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter. J Med Chem. 1992; 35 (13):2497-500.
In vitro analysis:
Kung M.P., Stevenson D.A., Plossl K., Meegalla S.K., Beckwith A., Essman W.D., Mu M., Lucki I., Kung H.F.. [99mTc]TRODAT-1: a novel technetium-99m complex as a dopamine transporter imaging agent. Eur J Nucl Med. 1997; 24 (4):372-80.
Dresel S.H., Kung M.P., Huang X., Plossl K., Hou C., Shiue C.Y., Karp J., Kung H.F.. In vivo imaging of serotonin transporters with [99mTc]TRODAT-1 in nonhuman primates. Eur J Nucl Med. 1999; 26 (4):342-7.
Animal Studies:
Hwang J.J., Liao M.H., Yen T.C., Wey S.P., Lin K.J., Pan W.H., Chen J.C., Ting G. Biodistribution study of [99mTc] TRODAT-1 alone or combined with other dopaminergic drugs in mice with macroautoradiography. Appl Radiat Isot. 2002; 57 (1):35-42.
Acton P.D., Choi S.R., Plossl K., Kung H.F. Quantification of dopamine transporters in the mouse brain using ultra-high resolution single-photon emission tomography. Eur J Nucl Med Mol Imaging. 2002; 29 (5):691-8.
Chen Y.K., Liu R.S., Huang W.S., Wey S.P., Ting G., Liu J.C., Shen Y.Y., Wan F.J.The role of dopamine transporter imaging agent [99mTc]TRODAT-1 in hemi-parkinsonism rat brain. Nucl Med Biol. 2001; 28 (8):923-8.
Fang P., Wu C.Y., Liu Z.G., Wan W.X., Wang T.S., Chen S.D., Chen Z.P., Zhou X.The preclinical pharmacologic study of dopamine transporter imaging agent [99mTc]TRODAT-1. Nucl Med Biol. 2000; 27 (1):69-75.
Dresel S.H., Kung M.P., Plossl K., Meegalla S.K., Kung H.F. Pharmacological effects of dopaminergic drugs on in vivo binding of [99mTc]TR...
Clinical Studies:
Ueda M, Iida Y, Mukai T, Mamede M, Ishizu K, Ogawa M, Magata Y, Konishi J, Saji H. 5-[123I]Iodo-A-85380: assessment of pharmacological safety, radiation dosimetry and SPECT imaging of brain nicotinic receptors in healthy human subjects. Ann Nucl Med. 2004; 18(4):337-344.
Weng Y.H., Yen T.C., Chen M.C., Kao P.F., Tzen K.Y., Chen R.S., Wey S.P., Ting G., Lu C.S. Sensitivity and specificity of 99mTc-TRODAT-1 SPECT imaging in differentiating patients with idiopathic Parkinson's disease from healthy subjects. J Nucl Med. 2004; 45 (3):393-401.
Wang J., Jiang Y.P., Liu X.D., Chen Z.P., Yang L.Q., Liu C.J., Xiang J.D., Su H.L. 99mTc-TRODAT-1 SPECT study in early Parkinson's disease and essential tremor. . Acta Neurol Scand. 2005; 112 (6):380-5.
Lin CY, Changlia SP, Huang CK, Lin MS, Yeh CH. Positive Tc-99m TRODAT findings in Japanese encephalitis. Clin Nucl Med. 2007 Jun;32(6):484-5.
Yeh CB, Lee CS, Ma KH, Lee MS, Chang CJ, Huang WS. Phasic dysfunction of dopamine transmission in Tourette's syndrome ev...