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Total tracers:   36
By Application: Oncology 15   By Isotope: Tc-99m 14
  Neurology 12     Ga-67/In-111 4
  Cardiology 12     I-123/I-125 17
  Nephrology 3     Tl-201 1

Active filter: id = 19 [disable]

Id SPECT Tracer Database
19
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Chemical name:123I/125I-Vascular endothelial growth factor
Common names:123I/ 125I-VEGF
Commercial product: 
Supplier:GE healthcare, PerkinElmer
Target:Vascular endothelial growth factor (VEGF) receptors
Mechanism:Receptor binding radiopharmaceutical
Application:Oncology  Cardiology  
Reported Use:Angiogenesis
Add. Comments: 
Isotope Family:I-123/I-125  
Publications:
Synthesis:
  • Li S, Peck-Radosavljevic M, Koller E, Koller F, Kaserer K, Kreil A, Kapiotis S, Hamwi A, Weich HA, Valent P, et al. Characterization of (123)I-vascular endothelial growth factor-binding sites expressed on human tumour cells: possible implication for tumour scintigraphy. Int J Cancer. 2001; 91(6):789-796
  • Yoshimoto M, Kinuya S, Kawashima A, Nishii R, Yokoyama K, Kawai K Radioiodinated VEGF to image tumor angiogenesis in a LS180 tumor xenograft model. Nuclear Medicine and Biology. 2006; 33 (8): 963-969
  • Bart Cornelissena, Ruth Oltenfreitera, Veerle Kersemansa, Ludovicus Staelensa, Francis Frankenneb, Jean-Michel Foidartb, Guido Slegersa. In vitro and in vivo evaluation of [123I]-VEGF165 as a potential tumor marker. Nuclear Medicine and Biology. 2005; 33 (5): 431-436
  • Specific activity reported: 1.66 GBq/nmol
  • In vitro analysis:
  • Li S, Peck-Radosavljevic M, Koller E, Koller F, Kaserer K, Kreil A, Kapiotis S, Hamwi A, Weich HA, Valent P, et al. Characterization of (123)I-vascular endothelial growth factor-binding sites expressed on human tumour cells: possible implication for tumour scintigraphy. Int J Cancer. 2001; 91(6):789-796.
  • Yoshimoto M, Kinuya S, Kawashima A, Nishii R, Yokoyama K, Kawai K Radioiodinated VEGF to image tumor angiogenesis in a LS180 tumor xenograft model. Nuclear Medicine and Biology. 2006; 33 (8): 963-969
  • Li S, Peck-Radosavljevic M, Kienast O, Preitfellner J, Havlik E, Schima W, Traub-Weidinger T, Graf S, Beheshti M, Schmid M, et al. Iodine-123-vascular endothelial growth factor-165 (123I-VEGF165). Biodistribution, safety and radiation dosimetry in patients with pancreatic carcinoma. Q J Nucl Med Mol Imaging. 2004; 48(3):198-206
  • Bart Cornelissena, Ruth Oltenfreitera, Veerle Kersemansa, Ludovicus Staelensa, Francis Frankenneb, Jean-Michel Foidartb, Guido Slegersa. In vitro and in vivo evaluation of [123I]-...
  • Animal Studies:
  • Li S, Peck-Radosavljevic M, Koller E, Koller F, Kaserer K, Kreil A, Kapiotis S, Hamwi A, Weich HA, Valent P, et al. Characterization of (123)I-vascular endothelial growth factor-binding sites expressed on human tumour cells: possible implication for tumour scintigraphy. Int J Cancer. 2001; 91(6):789-796.
  • Yoshimoto M, Kinuya S, Kawashima A, Nishii R, Yokoyama K, Kawai K Radioiodinated VEGF to image tumor angiogenesis in a LS180 tumor xenograft model. Nuclear Medicine and Biology. 2006; 33 (8): 963-969
  • Bart Cornelissena, Ruth Oltenfreitera, Veerle Kersemansa, Ludovicus Staelensa, Francis Frankenneb, Jean-Michel Foidartb, Guido Slegersa. In vitro and in vivo evaluation of [123I]-VEGF165 as a potential tumor marker. Nuclear Medicine and Biology. 2005; 33 (5): 431-436
  • Clinical Studies:
  • Li S, Peck-Radosavljevic M, Kienast O, Preitfellner J, Hamilton G, Kurtaran A, Pirich C, Angelberger P, Dudczak R. Imaging gastrointestinal tumours using vascular endothelial growth factor-165 (VEGF165) receptor scintigraphy. Ann Oncol. 2003; 14(8):1274-1277
  • Li S, Peck-Radosavljevic M, Kienast O, Preitfellner J, Havlik E, Schima W, Traub-Weidinger T, Graf S, Beheshti M, Schmid M, et al. Iodine-123-vascular endothelial growth factor-165 (123I-VEGF165). Biodistribution, safety and radiation dosimetry in patients with pancreatic carcinoma. Q J Nucl Med Mol Imaging. 2004; 48(3):198-206.
  • Shuren Li, Karl Roessler, Hossen Amadzadehfar, Elke Grumbeck, Karolina Wiesner, Christian Nasel, Christine Marosi, Peter Angelberger, Robert Dudczak. Imaging glioblastoma using iodine-123 labelled vascular endothelial growth factor-165 (123I-VEGF165). J Nucl Med. 2006; 47 (Supplement 1):80P
  • S. Graf, M. Beheshti, O. Kienast, S. Oezer, P. Angelberger, R. Dudczak, S. Shuren Li. Myocardial scintigraphy in patients with corona...
  • Examples
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