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Total tracers:   36
By Application: Oncology 15   By Isotope: Tc-99m 14
  Neurology 12     Ga-67/In-111 4
  Cardiology 12     I-123/I-125 17
  Nephrology 3     Tl-201 1

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Id SPECT Tracer Database
17
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Chemical name:99mTc-Arcitumomab
Common names: 
Commercial product:99mTc-IMMU-4, CEA-ScanŽ, 99mTc-NP-4 anti-CEA MAb Fab´
Supplier:Immunomedics
Target:Carcinoembryonic antigen (CEA)
Mechanism:Antigen-binding radiopharmaceutical
Application:Oncology  
Reported Use: 
Add. Comments: 
Isotope Family:Tc-99m  
Publications:
Synthesis:
  • Hansen HJ, Jones AL, Sharkey RM, Grebenau R, Blazejewski N, Kunz A, Buckley MJ, Newman ES, Ostella F, Goldenberg DM. Preclinical evaluation of an "instant" 99mTc-labeling kit for antibody imaging. Cancer Res. 1990; 50:794s-798s. 3 Suppl.
  • Linder KE, Wen MD, Nowotnik DP, Ramalingam K, Sharkey RM, Yost F, Narra RK, Nunn AD, Eckelman WC. Technetium labeling of monoclonal antibodies with functionalized BATOs: 2. TcCl(DMG)3CPITC labeling of B72.3 and NP-4 whole antibodies and NP-4 F(ab')2. Bioconjug Chem. 1991; 2(6):407-414.
  • Hansen HJ, Jones AL, Grebenau R, Kunz A, Goldenberg DM. Labeling of anti-tumor antibodies and antibody fragments with Tc-99m. Cancer Treat Res. 1990; 51:233-244.
  • In vitro analysis:
  • Primus FJ, Freeman JW, Goldenberg DM. Immunological heterogeneity of carcinoembryonic antigen: purification from meconium of an antigen related to carcinoembryonic antigen. Cancer Res. 1983; 43(2):679-685.
  • Hansen HJ, Jones AL, Sharkey RM, Grebenau R, Blazejewski N, Kunz A, Buckley MJ, Newman ES, Ostella F, Goldenberg DM. Preclinical evaluation of an "instant" 99mTc-labeling kit for antibody imaging. Cancer Res. 1990; 50:794s-798s. 3 Suppl.
  • Animal Studies:
  • Hansen HJ, Jones AL, Sharkey RM, Grebenau R, Blazejewski N, Kunz A, Buckley MJ, Newman ES, Ostella F, Goldenberg DM. Preclinical evaluation of an "instant" 99mTc-labeling kit for antibody imaging. Cancer Res. 1990; 50:794s-798s. 3 Suppl
  • Linder KE, Wen MD, Nowotnik DP, Ramalingam K, Sharkey RM, Yost F, Narra RK, Nunn AD, Eckelman WC. Technetium labeling of monoclonal antibodies with functionalized BATOs: 2. TcCl(DMG)3CPITC labeling of B72.3 and NP-4 whole antibodies and NP-4 F(ab')2. Bioconjug Chem. 1991; 2(6):407-414.
  • Clinical Studies:
  • Moffat FL, Pinsky CM, Hammershaimb L, Petrelli NJ, Patt YZ, Whaley FS, Goldenberg DM. Clinical utility of external immunoscintigraphy with the IMMU-4 technetium-99m Fab' antibody fragment in patients undergoing surgery for carcinoma of the colon and rectum: results of a pivotal, phase III trial. The Immunomedics Study Group. J Clin Oncol. 1996; 14(8):2295-2305.
  • Libutti SK, Alexander HR, Choyke P, Bartlett DL, Bacharach SL, Whatley M, Jousse F, Eckelman WC, Kranda K, Neumann RD, et al. A prospective study of 2-[18F] fluoro-2-deoxy-D-glucose/positron emission tomography scan, 99mTc-labeled arcitumomab (CEA-scan), and blind second-look laparotomy for detecting colon cancer recurrence in patients with increasing carcinoembryonic antigen levels. Ann Surg Oncol. 2001; 8(10):779-786.
  • Willkomm P, Bender H, Bangard M, Decker P, Grunwald F, Biersack HJ. FDG PET and immunoscintigraphy with 99mTc-labeled antibody fragments for detection of the recurrence of colorectal carcinoma. J Nucl Med. 2000; 41(10):1657-1663.
  • Examples
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