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Total tracers:   36
By Application: Oncology 15   By Isotope: Tc-99m 14
  Neurology 12     Ga-67/In-111 4
  Cardiology 12     I-123/I-125 17
  Nephrology 3     Tl-201 1

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Id SPECT Tracer Database
14
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Chemical name:99mTc-Dimercaptosuccinic acid
Common names: 
Commercial product:99mTc-DMSA
Supplier:Local radiopharmacy, GE Healthcare
Target:N/A
Mechanism:Urinary clearance
Application:Nephrology  
Reported Use: 
Add. Comments: 
Isotope Family:Tc-99m  
Publications:
Synthesis:
  • Westera G, Gadze A, Horst W. A convenient method for the preparation of 99mTc(V)dimercaptosuccinic acid (99mTc(V)-DMSA). Int J Appl Radiat Isot. 1985 Apr;36(4):311-2.
  • Washburn LC, Biniakiewicz DS, Maxon HR 3rd. Reliable preparation of 99mTc (V) DMSA by a simple modified method using a commercial kit for 99mTc (III) DMSA. Nucl Med Biol. 1995 Jul;22(5):689-91.
  • Kobayashi H, Suzuki KH, Sakahara H, Yao ZS, Yokoyama A, Konishi J. Oxygen bubbling can improve the labelling of pentavalent technetium-99m dimercaptosuccinic acid. Eur J Nucl Med. 1995 Jun;22(6):559-62.
  • In vitro analysis:
    Animal Studies:
  • Taylor A Jr, Lallone RL, Hagan PL. Optimal handling of dimercaptosuccinic acid for quantitative renal scanning. J Nucl Med. 1980 Dec;21(12):1190-3.
  • Yee CA, Lee HB, Blaufox MD. Tc-99m DMSA renal uptake: influence of biochemical and physiologic factors. J Nucl Med. 1981 Dec;22(12):1054-8.
  • Goldraich NP, Alvarenga AR, Goldraich IH, Ramos OL, Sigulem D. Renal accumulation of 99mTc-DMSA in the artificially perfused isolated rat kidney. J Urol. 1985 Dec;134(6):1282-6.
  • Forrer F, Valkema R, Bernard B, Schramm NU, Hoppin JW, Rolleman E, Krenning EP, de Jong M. In vivo radionuclide uptake quantification using a multi-pinhole SPECT system to predict renal function in small animals. Eur J Nucl Med Mol Imaging. 2006 Oct;33(10):1214-7
  • Clinical Studies:
  • van Luijk WH, Piers DA, Beekhuis H, Meijer S. Renal handling of technetium-99m DMSA: further evidence for glomerular filtration and proximal tubular reabsorption. J Nucl Med. 1986 Dec;27(12):1943.
  • Hosokawa S, Kawamura J, Tomoyoshi T, Yoshida O. Congenital renal anomaly: evaluation with 99mTc-dimercaptosuccinic acid renal scintigraphy. Am J Kidney Dis. 1983 May;2(6):655-9.
  • van Luijk WH, Ensing GJ, Meijer S, Donker AJ, Piers DA. Is the relative 99mTc-DMSA clearance a useful marker of proximal tubular dysfunction? Eur J Nucl Med. 1984;9(10):439-42.
  • Groshar D, Frankel A, Iosilevsky G, Israel O, Moskovitz B, Levin DR, Front D. Quantitation of renal uptake of technetium-99m DMSA using SPECT. J Nucl Med. 1989 Feb;30(2):246-50.
  • Daly MJ, Henry RE. Defining renal anatomy and function with 99mtechnetium dimercaptosuccinic acid: clinical and renographic correlation. J Urol. 1981 Jul;126(1):5-9.
  • Yen TC, Chen WP, Chang SL, Liu RS, Yeh SH, Lin CY. Technetium-99m-DMSA renal SPECT in diagnosing and monitoring...
  • Examples
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