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Total tracers:   36
By Application: Oncology 15   By Isotope: Tc-99m 14
  Neurology 12     Ga-67/In-111 4
  Cardiology 12     I-123/I-125 17
  Nephrology 3     Tl-201 1

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Id SPECT Tracer Database
13
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Chemical name:99mTc-Mercaptoacetyltriglycine
Common names: 
Commercial product:99mTc-MAG3, TechneScan MAG3
Supplier:Local radiopharmacy, Tyco Healthcare
Target:N/A
Mechanism:Tubular secretion and glomerular filtration
Application:Nephrology  
Reported Use: 
Add. Comments: 
Isotope Family:Tc-99m  
Publications:
Synthesis:
  • Brandau W, Bubeck B, Eisenhut M, Taylor DM.Technetium-99m labeled renal function and imaging agents: III. Synthesis of 99mTc-MAG3 and biodistribution of by-products. Int J Rad Appl Instrum [A]. 1988;39(2):121
  • Coveney JR, Robbins MS. Comparison of technetium-99m MAG3 kit with HPLC-purified technetium-99m MAG3 and OIH in rats. J Nucl Med. 1987 Dec;28(12):1881-7.
  • Fritzberg AR, Kasina S, Eshima D, Johnson DL. Synthesis and biological evaluation of technetium-99m MAG3 as a hippuran replacement. J Nucl Med. 1986 Jan;27(1):111-6.
  • In vitro analysis:
    Animal Studies:
  • • Coveney JR, Robbins MS. Comparison of technetium-99m MAG3 kit with HPLC-purified technetium-99m MAG3 and OIH in rats. J Nucl Med. 1987 Dec;28(12):1881-7. Lee HB, Blaufox MD. Technetium-99m MAG-3 clearances after captopril in experimental renovascular hypertension. J Nucl Med. 1989 ;30(5):666-71.
  • Eshima D, Taylor A Jr, Fritzberg AR, Kasina S, Hansen L, Sorenson JF. Animal evaluation of technetium-99m triamide mercaptide complexes as potential renal imaging agents. J Nucl Med. 1987 Jul;28(7):1180-6.
  • Fritzberg AR, Kasina S, Eshima D, Johnson DL. Synthesis and biological evaluation of technetium-99m MAG3 as a hippuran replacement. J Nucl Med. 1986 Jan;27(1):111-6.
  • Clinical Studies:
  • Taylor A Jr, Eshima D, Fritzberg AR, Christian PE, Kasina S. Comparison of iodine-131 OIH and technetium-99m MAG3 renal imaging in volunteers. J Nucl Med. 1986 Jun;27(6):795-803.
  • Taylor A Jr, Eshima D, Christian PE, Milton W. Evaluation of Tc-99m mercaptoacetyltriglycine in patients with impaired renal function. Radiology. 1987 Feb;162(2):365-70.
  • Jafri RA, Britton KE, Nimmon CC, Solanki K, Al-Nahhas A, Bomanji J, Fettich J, Hawkins L. Technetium-99m MAG3, a comparison with iodine-123 and iodine-131 orthoiodohippurate, in patients with renal disorders. J Nucl Med. 1988 Feb;29(2):147-58.
  • Rehling M, Nielsen BV, Pedersen EB, Nielsen LE, Hansen HE, Bacher T. Renal and extrarenal clearance of 99mTc-MAG3: a comparison with 125I-OIH and 51Cr-EDTA in patients representing all levels of glomerular filtration rate. Eur J Nucl Med. 1995 Dec;22(12):1379-84.
  • Tulchinsky M, Dietrich TJ, Eggli DF, Yang HC. Technetium-99m-MAG3 scintigraphy in acute renal failure after transplantation: a marker of viability and pro...
  • Examples
    Rat Kidney Tc-99m-MAG3 (animation and plot)
    2006-06-05
    Erasmus MC, Rotterdam
    Rat Kidney Tc-99m-MAG3 (dynamic uptake and clearance study, SPECT/CT)
    0000-00-00
    Erasmus MC, Rotterdam
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