| Publications: |
| Synthesis: |
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| In vitro analysis: |
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| Perek N, Le Jeune N, Denoyer D, Dubois F. MRP-1 protein expression and glutathione content of in vitro tumor cell lines derived from human glioma carcinoma U-87-MG do not interact with 99mTc-glucarate uptake. Cancer Biother Radiopharm. 2005 Aug;20(4):391-400.Ballinger JR, Hsue V, Rauth AM. Accumulation of technetium-99m glucarate: in vitro cell cultures and in vivo tumour models. Nucl Med Commun. 2003 May;24(5):597-606. Narula J, Petrov A, Pak KY, Ditlow C, Chen F, Khaw BA. Noninvasive detection of atherosclerotic lesions by 99mTc-based immunoscintigraphic targeting of proliferating smooth muscle cells. Chest. 1997 Jun;111(6):1684-90. Ballinger JR, Cowan DS, Boxen I, Zhang ZM, Rauth AM. Effect of hypoxia on the accumulation of technetium-99m-glucarate and technetium-99m-gluconate by Chinese hamster ovary cells in vitro. J Nucl Med. 1993 Feb;34(2):242-5. |
| Animal Studies: |
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| Johnson G 3rd, Okada CC, Hocherman SD, Liu Z, Hart C, Khaw BA, Okada RD. (99m)Tc-glucarate imaging for the early detection of infarct in partially reperfused canine myocardium. Eur J Nucl Med Mol Imaging. 2006 Mar;33(3):319-28. Liu Z, Barrett HH, Stevenson GD, Kastis GA, Bettan M, Furenlid LR, Wilson DW, Pak KY. High-resolution imaging with (99m)Tc-glucarate for assessing myocardial injury in rat heart models exposed to different durations of ischemia with reperfusion. J Nucl Med. 2004 Jul;45(7):1251-9. Liu Z, Stevenson GD, Barrett HH, Kastis GA, Bettan M, Furenlid LR, Wilson DW, Woolfenden JM, Pak KY. 99mTc glucarate high-resolution imaging of drug sensitive and drug resistant human breast cancer xenografts in SCID mice. Nucl Med Commun. 2004 Jul;25(7):711-20.Okada DR, Johnson G, Liu Z, Hocherman SD, Khaw BA, Okada RD. Early detection of infarct in reperfused canine myocardium using 99mTc-glucarate.J Nucl Med. 2004 Apr;45(4):655-64. Ballinger JR, Hsue V, Rauth AM. Accumulation of technetium-... |
| Clinical Studies: |
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| Mariani G, Villa G, Rossettin PF, Spallarossa P, Bezante GP, Brunelli C, Pak KY, Khaw BA, Strauss HW. Detection of acute myocardial infarction by 99mTc-labeled D-glucaric acid imaging in patients with acute chest pain. J Nucl Med. 1999 Nov;40(11):1832-9. Wiersema AM, Oyen WJ, Dirksen R, Verhofstad AA, Corstens FH, van der Vliet JA. Early assessment of skeletal muscle damage after ischaemia-reperfusion injury using Tc-99m-glucarate. Cardiovasc Surg. 2000 Apr;8(3):186-91. |
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